Table 3 Statistical results for mRNA and protein levels when analysed by inflammatory subgroup
From: Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
| Marker | Overall ANOVA | CTRL low vs SCZ low | CTRL low vs SCZ high | SCZ low vs SCZ high |
|---|---|---|---|---|
| GAD1 mRNA | F(2,49) = 7.551; p = 0.001** | 30.10%; p < 0.001*** | 31.88%; p < 0.001*** | p = 0.655 |
| GAD65/67 protein | F(2,46) = 2.895, p = 0.065 | |||
| PV mRNA | F(2,51) = 2.751, p = 0.073 | |||
| SST mRNA | F(2,49) = 1.859, p = 0.167 | |||
| VGAT mRNA | F(2,52) = 8.281, p = 0.001** | 28.66%; p = 0.018* | 43.94%; p < 0.001*** | p = 0.177 |
| GABRA1 mRNA | F(2,51) = 9.221, p < 0.0001**** | 34.91%, p = 0.004** | 44.85%, p < 0.0001**** | p = 0.368 |
| GABRA2 mRNA | F(2,50) = 2.605, p = 0.084 | |||
| GABRA3 mRNA | F(2,50) = 9.788; p = 0.0001**** | p = 0.181 | 35.68%, p < 0.0001**** | 27.72%, p = 0.007** |
| GABRA3 protein | F(2,40) = 1.157, p = 0.325 | |||
| GABRA5 mRNA | F(2,49) = 1.555, p = 0.221 | |||